ITIH2

ITIH2
معرفات
أسماء بديلة	ITIH2, H2P, SHAP, inter-alpha-trypsin inhibitor heavy chain 2
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 146640 MGI: MGI:96619 HomoloGene: 1668 GeneCards: 3698
علم الوجود الجيني
وظائف جزيئية	• peptidase inhibitor activity; • endopeptidase inhibitor activity; • serine-type endopeptidase inhibitor activity;
مكونات خلوية	• blood microparticle; • حويصلة خارج خلوية; • الفراغ خارج الخلية; • endoplasmic reticulum lumen; • collagen-containing extracellular matrix;
عمليات حيوية	• hyaluronan metabolic process; • negative regulation of peptidase activity; • negative regulation of endopeptidase activity; • تعديل ما بعد الترجمة;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
تماثلات متسلسلة
	P19823
	Q61703
	NM_002216
	NM_010582
	NP_002207
	NP_034712
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

ITIH2‏ (Inter-alpha-trypsin inhibitor heavy chain 2) هوَ بروتين يُشَفر بواسطة جين ITIH2 في الإنسان.^[1]^[2]^[3]

الوظيفة

الأهمية السريرية

المراجع

^ "Entrez Gene: ITIH2 inter-alpha (globulin) inhibitor H2". مؤرشف من الأصل في 2010-12-05.
^ Jean L، Risler JL، Nagase T، Coulouarn C، Nomura N، Salier JP (مايو 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. ج. 446 ع. 1: 6–8. DOI:10.1016/S0014-5793(99)00173-8. PMID:10100603.
^ Salier JP، Simon D، Rouet P، Raguenez G، Muscatelli F، Gebhard W، Guenet JL، Mattei MG (ديسمبر 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. ج. 14 ع. 1: 83–8. DOI:10.1016/S0888-7543(05)80287-3. PMID:1385302.

قراءة متعمقة

Malki N، Balduyck M، Maes P، وآخرون (1992). "The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A.". Biol. Chem. Hoppe-Seyler. ج. 373 ع. 10: 1009–18. DOI:10.1515/bchm3.1992.373.2.1009. PMID:1384548.
Salier JP، Diarra-Mehrpour M، Sesboue R، وآخرون (1988). "Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI". Proc. Natl. Acad. Sci. U.S.A. ج. 84 ع. 23: 8272–6. DOI:10.1073/pnas.84.23.8272. PMC:299524. PMID:2446322.
Gebhard W، Schreitmüller T، Hochstrasser K، Wachter E (1988). "Complementary DNA and derived amino acid sequence of the precursor of one of the three protein components of the inter-alpha-trypsin inhibitor complex". FEBS Lett. ج. 229 ع. 1: 63–7. DOI:10.1016/0014-5793(88)80798-1. PMID:2450046.
Salier JP، Diarra-Mehrpour M، Sesboüé R، وآخرون (1989). "Human inter-alpha-trypsin inhibitor. Isolation and characterization of heavy (H) chain cDNA clones coding for a 383 amino-acid sequence of the H chain". Biol. Chem. Hoppe-Seyler. 369 Suppl: 15–8. PMID:2462430.
Diarra-Mehrpour M، Bourguignon J، Sesboüé R، وآخرون (1989). "Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes". Eur. J. Biochem. ج. 179 ع. 1: 147–54. DOI:10.1111/j.1432-1033.1989.tb14532.x. PMID:2465147.
Enghild JJ، Thøgersen IB، Pizzo SV، Salvesen G (1989). "Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan". J. Biol. Chem. ج. 264 ع. 27: 15975–81. PMID:2476436.
Schreitmüller T، Hochstrasser K، Reisinger PW، وآخرون (1987). "cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins". Biol. Chem. Hoppe-Seyler. ج. 368 ع. 8: 963–70. DOI:10.1515/bchm3.1987.368.2.963. PMID:3663330.
Huang L، Yoneda M، Kimata K (1994). "A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor". J. Biol. Chem. ج. 268 ع. 35: 26725–30. PMID:7504674.
Morelle W، Capon C، Balduyck M، وآخرون (1994). "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor". Eur. J. Biochem. ج. 221 ع. 2: 881–8. DOI:10.1111/j.1432-1033.1994.tb18803.x. PMID:7513643.
Wisniewski HG، Burgess WH، Oppenheim JD، Vilcek J (1994). "TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor". Biochemistry. ج. 33 ع. 23: 7423–9. DOI:10.1021/bi00189a049. PMID:7516184.
Enghild JJ، Salvesen G، Thøgersen IB، وآخرون (1993). "Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin". J. Biol. Chem. ج. 268 ع. 12: 8711–6. PMID:7682553.
Maruyama K، Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. ج. 138 ع. 1–2: 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID:8125298.
Mizon C، Balduyck M، Albani D، وآخرون (1996). "Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains". J. Immunol. Methods. ج. 190 ع. 1: 61–70. DOI:10.1016/0022-1759(95)00257-X. PMID:8601712.
Suzuki Y، Yoshitomo-Nakagawa K، Maruyama K، وآخرون (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. ج. 200 ع. 1–2: 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID:9373149.
Olsen EH، Rahbek-Nielsen H، Thogersen IB، وآخرون (1998). "Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2". Biochemistry. ج. 37 ع. 1: 408–16. DOI:10.1021/bi971137d. PMID:9425062.
Mizushima S، Nii A، Kato K، Uemura A (1998). "Gene expression of the two heavy chains and one light chain forming the inter-alpha-trypsin-inhibitor in human tissues". Biol. Pharm. Bull. ج. 21 ع. 2: 167–9. DOI:10.1248/bpb.21.167. PMID:9514613.
Flahaut C، Capon C، Balduyck M، وآخرون (1998). "Glycosylation pattern of human inter-alpha-inhibitor heavy chains". Biochem. J. ج. 333 ع. 3: 749–56. PMC:1219641. PMID:9677337.
Hamm A، Veeck J، Bektas N، وآخرون (2008). "Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysis". BMC Cancer. ج. 8 ع. 25: 25. DOI:10.1186/1471-2407-8-25. PMC:2268946. PMID:18226209.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)

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[entrez-1] "Entrez Gene: ITIH2 inter-alpha (globulin) inhibitor H2". مؤرشف من الأصل في 2010-12-05.

[pmid10100603-2] Jean L، Risler JL، Nagase T، Coulouarn C، Nomura N، Salier JP (مايو 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. ج. 446 ع. 1: 6–8. DOI:10.1016/S0014-5793(99)00173-8. PMID:10100603.

[pmid1385302-3] Salier JP، Simon D، Rouet P، Raguenez G، Muscatelli F، Gebhard W، Guenet JL، Mattei MG (ديسمبر 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. ج. 14 ع. 1: 83–8. DOI:10.1016/S0888-7543(05)80287-3. PMID:1385302.

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