IGFBP6
جين من أنواع جينات الإنسان العاقل
IGFBP6 (Insulin like growth factor binding protein 6) هوَ بروتين يُشَفر بواسطة جين IGFBP6 في الإنسان.[1][2][3]
الوظيفة
عدلهذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
الأهمية السريرية
عدلهذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
المراجع
عدل- ^ Kiefer MC، Ioh RS، Bauer DM، Zapf J (مايو 1991). "Molecular cloning of a new human insulin-like growth factor binding protein". Biochem Biophys Res Commun. ج. 176 ع. 1: 219–25. DOI:10.1016/0006-291X(91)90912-Q. PMID:1850258.
- ^ Ehrenborg E، Zazzi H، Lagercrantz S، Granqvist M، Hillerbrand U، Allander SV، Larsson C، Luthman H (مايو 1999). "Characterization and chromosomal localization of the human insulin-like growth factor-binding protein 6 gene". Mamm Genome. ج. 10 ع. 4: 376–80. DOI:10.1007/s003359901005. PMID:10087296.
- ^ "Entrez Gene: IGFBP6 insulin-like growth factor binding protein 6". مؤرشف من الأصل في 2010-12-05.
قراءة متعمقة
عدل- Wood AW، Duan C، Bern HA (2005). "Insulin-like growth factor signaling in fish". Int. Rev. Cytol. International Review of Cytology. ج. 243: 215–85. DOI:10.1016/S0074-7696(05)43004-1. ISBN:9780123646477. PMID:15797461.
- Zapf J، Kiefer M، Merryweather J، وآخرون (1990). "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia". J. Biol. Chem. ج. 265 ع. 25: 14892–8. PMID:1697583.
- Kiefer MC، Masiarz FR، Bauer DM، Zapf J (1991). "Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum". J. Biol. Chem. ج. 266 ع. 14: 9043–9. PMID:1709161.
- Shimasaki S، Gao L، Shimonaka M، Ling N (1991). "Isolation and molecular cloning of insulin-like growth factor-binding protein-6". Mol. Endocrinol. ج. 5 ع. 7: 938–48. DOI:10.1210/mend-5-7-938. PMID:1719383.
- Andress DL، Birnbaum RS (1991). "A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells". Biochem. Biophys. Res. Commun. ج. 176 ع. 1: 213–8. DOI:10.1016/0006-291X(91)90911-P. PMID:1850257.
- Martin JL، Willetts KE، Baxter RC (1990). "Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human fibroblasts". J. Biol. Chem. ج. 265 ع. 7: 4124–30. PMID:2154495.
- Roghani M، Hossenlopp P، Lepage P، وآخرون (1989). "Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II". FEBS Lett. ج. 255 ع. 2: 253–8. DOI:10.1016/0014-5793(89)81101-9. PMID:2551732.
- Ilvesmäki V، Blum WF، Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. ج. 97 ع. 1–2: 71–9. DOI:10.1016/0303-7207(93)90212-3. PMID:7511544.
- Kato M، Ishizaki A، Hellman U، وآخرون (1995). "A human keratinocyte cell line produces two autocrine growth inhibitors, transforming growth factor-beta and insulin-like growth factor binding protein-6, in a calcium- and cell density-dependent manner". J. Biol. Chem. ج. 270 ع. 21: 12373–9. DOI:10.1074/jbc.270.21.12373. PMID:7539002.
{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link) - Delhanty PJ، Hill DJ، Shimasaki S، Han VK (1993). "Insulin-like growth factor binding protein-4, -5 and -6 mRNAs in the human fetus: localization to sites of growth and differentiation?". Growth Regul. ج. 3 ع. 1: 8–11. PMID:7683540.
- Bach LA، Hsieh S، Sakano K، وآخرون (1993). "Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6". J. Biol. Chem. ج. 268 ع. 13: 9246–54. PMID:7683646.
- Wegmann BR، Schöneberger HJ، Kiefer PE، وآخرون (1993). "Molecular cloning of IGFBP-5 from SCLC cell lines and expression of IGFBP-4, IGFBP-5 and IGFBP-6 in lung cancer cell lines and primary tumours". Eur. J. Cancer. ج. 29A ع. 11: 1578–84. DOI:10.1016/0959-8049(93)90298-T. PMID:7692907.
- Neumann GM، Marinaro JA، Bach LA (1998). "Identification of O-glycosylation sites and partial characterization of carbohydrate structure and disulfide linkages of human insulin-like growth factor binding protein 6". Biochemistry. ج. 37 ع. 18: 6572–85. DOI:10.1021/bi972894e. PMID:9572875.
- Neumann GM، Bach LA (1999). "The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry". J. Biol. Chem. ج. 274 ع. 21: 14587–94. DOI:10.1074/jbc.274.21.14587. PMID:10329650.
{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link) - Wong MS، Fong CC، Yang M (1999). "Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins". Biochim. Biophys. Acta. ج. 1432 ع. 2: 293–301. DOI:10.1016/S0167-4838(99)00106-5. PMID:10407151.
- Yu H، Mistry J، Nicar MJ، وآخرون (1999). "Insulin-like growth factors (IGF-I, free IGF-I and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation". J. Clin. Lab. Anal. ج. 13 ع. 4: 166–72. DOI:10.1002/(SICI)1098-2825(1999)13:4<166::AID-JCLA5>3.0.CO;2-X. PMID:10414596.
- Dailly YP، Zhou Y، Linkhart TA، وآخرون (2001). "Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: identification of a functional retinoid response element". Biochim. Biophys. Acta. ج. 1518 ع. 1–2: 145–51. DOI:10.1016/S0167-4781(01)00192-0. PMID:11267670.
- Weinzimer SA، Gibson TB، Collett-Solberg PF، وآخرون (2001). "Transferrin is an insulin-like growth factor-binding protein-3 binding protein". J. Clin. Endocrinol. Metab. ج. 86 ع. 4: 1806–13. DOI:10.1210/jcem.86.4.7380. PMID:11297622.
